Qualitative assessment of leachables using data‐dependent liquid chromatography/mass spectrometry and liquid chromatography/tandem mass spectrometry
نویسندگان
چکیده
منابع مشابه
Liquid Chromatography - Mass Spectrometry
In this article, selected examples of applications of liquid chromatography coupled to mass spectrometry are given. The examples include the analysis of i) impurities in manufactured, pharmaceutical or synthesis products, ii) polyphenols in natural products, and iii) phytohormones in plant extracts. Finally, examples of applications of molecular characterization via flow injection analysis by e...
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Liquid secondary-ion mass spectrometry (liquid SIMS) is an obsolescent ionization technique that revolutionized the analyses of large biological molecules in the 1980s. The term includes fast atom bombardment mass spectrometry (FAB-MS). The technique has been largely superseded by electrospray ionization. This account will cover the history of the technique, the principles of the operation, and...
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INTRODUCTION By means of liquid-liquid extraction with ethyl acetate, a rapid, sensitive, and specific LC-MS/MS method was developed and validated for assaying ponatinib and the internal standard, warfarin. METHODS The method was verified and successfully applied to evaluate the pharmacokinetics of ponatinib in Sprague-Dawley rats. RESULTS Ponatinib showed dose-dependent exposure in the cir...
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ژورنال
عنوان ژورنال: Rapid Communications in Mass Spectrometry
سال: 1997
ISSN: 0951-4198,1097-0231
DOI: 10.1002/(sici)1097-0231(199709)11:14<1570::aid-rcm985>3.3.co;2-4